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Animal-human hybrid embryos are unethical and unnecessary

The following is a response from Dr Donald Bruce, of the Church's Society Religion and Technology Project (SRTP), about human-animal hybrid embryos: SRTP logo
The Church of Scotland welcomes the decision by the Human Fertilisation and Embryology Authority to have a full public debate and consultation on whether to license research on human-animal hybrid embryos. The Church’s General Assembly is not opposed to all research involving embryonic stem cells, but its has expressly opposed to research involving the creation of human-animal ‘hybrid’ cloned embryos.

Christian teaching on compassion for the sick welcomes and indeed stimulates scientific research in medicine, but always within moral limits. Some experiments, no matter how medically useful, would be unethical. Research with animal-human cloned embryos would breach moral norms. It is highly speculative scientifically, decades from any clinical application, and other methods exist to the same end. It is both unethical and unnecessary. Here is a proper limit for research.

Not an ethical solution

The 2006 General Assembly debated stem cells at length and accepted that the creation of cloned embryos using human eggs might be justified under very exceptional cases. The isolation of diseased cells to study motor neurone disease might be one such case. But the 2002 and 2006 Assemblies both rejected the use of animal eggs to create hybrid cloned embryos.

The cross-species admixture of reproductive cells poses significant ethical concerns. Even though only 1% of animal material is involved, it is still a form of hybridisation. Contrary to some claims by scientists, the UK law requires that a human embryo be given more respect than merely cells in a petri dish. It is hard to see what respect is being shown in creating an embryo, purely to extract cells from it, which is both a hybrid of human and animal, and which is thereby so disrupted that it could never be viable.

We also hold that humans and animals, though having many similarities, are nonetheless different in more than just the biological distinctions among species. To create chimeric reproductive entities of mixed status, even if non-viable, would breach the distinction between human and animal more fundamentally than acceptable examples like a sheep expressing a single human gene in its milk, or a functioning pig kidney inside a human body. Here is a line not to be crossed.

Unnecessary

It is also unnecessary, scientifically very uncertain and potentially risky. We are inclined to agree with the 2000 Chief Medical Officer’s committee’s review of stem cell research, which formed the basis of current UK legislation, that "the use of eggs from a non-human species to carry a human nucleus was not a realistic or desirable solution to the lack of human eggs for research." Having reviewed the evidence so far, the HFEA conclude that “there is not clear agreement within the scientific community about the need for and benefits of this science.”

When the motor neurone disease research was proposed in 2004 the scientists gave no indication of needing hybrid embryos. Hitherto researchers have considered that human eggs are sufficient for this kind of experiment. Trying to reprogramme human cells back to an embryonic state using animal eggs is even more doubtful than is cloning with human eggs. Mixing species would introduce uncertainties as to the validity for use of the cells produced. It also runs against the current trend to eliminate animal ‘feeder’ cells in the generation of embryonic stem cell lines.

Not ‘delaying cures’

The claim that to deny such experiments would delay cures for terminal diseases is irresponsible and unjustified. Delay might be a significant factor if this was a near certain therapeutic method, where animal cells alone would give the missing breakthrough. In this case, it is basic research of uncertain outcome, many years, perhaps decades, from clinical application, and about which other scientists raise substantial technical doubts.

We are concerned more generally at premature expectations about stem cell research being raised by these kinds of claims, especially following the Korean cloning scandal.

Ends

11 January 2007

nr/02/01/07

Note to news desks

For further information please contact senior media relations officer Grant McLennan on 0131 240 2204 or email gmclennan@cofscotland.org.uk

More information about the SRTP is available online here or click here to visit their website. Please note this link will take you out of the Church of Scotland website and open a new browser window.

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